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Centralisation Centralisation is a phenomenon by which distal limb pain emanating from the spine is immediately or eventually abolished in response to the deliberate application of loading strategies. Such loading causes an abolition of peripheral pain that appears to progressively retreat in a proximal direction. As this occurs there may be a simultaneous development or increase in proximal pain. It only occurs in the derangement syndrome. Centralisation is a very favourable phenomenon and is an indicator of good treatment outcome. Whatever treatment is given to the patient, when centralisation is present this means that the treatment given is favourable.
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