 Hyaluronan is a high molecular weight biopolymer which is present in many of our tissues as an important component of the extracellular matrix. In the joint cartilage, hyaluronan is the backbone of the proteoglycans, which - together with collagen fibers - forms a matrix, in which the chondrocytes are embedded. Hyaluronan, at the same time, provides viscosity to the synovial fluid for its shock absorbing and lubricating properties. It furthermore acts as a molecular sieve (picture) and coats the pain receptors.
In osteoarthritis, the homeostasis of this system is severely disturbed due to the fact that hyaluronan in the synovial fluid is fragmented and diluted. Pain and restricted joint movement under load are then limiting the patient's daily live activities.
Upgrading the concentration and the molecular weight in the synovial fluid by intra-articular administration of exogenous hyaluronan (called viscosupplementation) has become very common in the symptomatic treatment of osteoarthritis. Medical societies propose this type of treatment already when the use of plain analgesics or nonsteroidal antirheumatic drugs is contraindicated, complicated by adverse drug reactions or ineffective in terms of pain reduction.
Intra-articular hyaluronan has been proven as safe and effective in numerous clinical studies. One of the main advantages of this treatment is its reliable and long-lasting carry over effect after a few injections only. The range of certified medical devices, which is available under the brand of Ostenil, has been used for more than ten years now in the successful treatment of osteoarthritis of bigger joints (like knee, hip and shoulder) and of smaller joints (CMC, hallux and facet joint of the spine) as well. The medium molecular weight of hyaluronan from fermentation and the terminal sterilization of the syringe in its blister confer to the safety and efficacy of Ostenil, one of the leading products in the market..
Special thanks to Mrs. Christiane Greiff, Area Manager. |
Back ... |
|
|
|
 |
|
|
|
|
Invest in Efficient Knowledge |
|
|
|
Contact : Steven De Coninck, MSc PT |
|
|
|
Lepelemstraat 4 |
|
|
|
B 8421 De Haan, Belgium |
|
|
|
E-mail: info@etgom.be |
|
|
|
Tel.: ++32 475 730 911 |
|
|
|
GSM: www.cyriaxlatinoamerica.com |
|
|
|
Fax: www.cyriax.com.pl |
|
|
|
|
|
 |
|
|
|
|
|
© European Teaching Group of Orthopaedic Medicine 2013 |
|
|
|
www.om-cyriax.com |
|
|
|
|
|
|
|
